Hope: Psoriasis and Psoriatic Arthritis Treatments in Clinical Trials
While treatments for psoriasis and psoriatic arthritis
are expanding, many people continue to need
additional options.
What follows is information on the dozens of experimental treatments in development by the pharmaceutical and biotech
industries, specifically for psoriasis and psoriatic arthritis.
Many of these will never make it to market, but many of them
WILL.
Perhaps one of these will help you or one of your loved ones someday.
(Note: We have not included the dozens of treatments being studied for
rheumatoid arthritis, even though some of them will almost certainly end
up helping psoriasis and/or psoriatic arthritis patients as well.)
If you think you may want to participate in a clinical trial, visit the
U.S. Government's clinical trials website for psoriasis
and psoriatic arthritis.
Be hopeful!
III
Phase III
Phase Three clinical trials are advanced trials for drugs that could
come to market in anywhere from a few months to a couple years, if the
results for safety and effectiveness pan out. These are the drugs closest to
market. An estimated 70% to 90% of drugs will succeed in Phase Three
trials and reach patients.
II
Phase II
Phase Two clinical trials have passed an initial screening in human
subjects, and based on that limited data, appear safe. Scientists also
typically have some theory at this stage for why a particular compound
may help a particular disease. Phase Two studies test a drug for
effectiveness. These drugs are typically 3-5 years away from market,
provided the Phase Two and later Phase Three trials prove successful.
About one-third of drugs that enter Phase One studies proceed
successfully through both Phase One and Phase Two trials.
| DRUG NAME |
DRUG USE (P OR PsA) |
DEVELOPING COMPANY |
| Actos (Pioglitazone) |
Plaque psoriasis; insulin resistance |
Postgraduate Institute of Medical Education and Research, India; Cairo University |
| AMG 714 |
Moderate to severe psoriasis |
Amgen, Genmab |
| AN2728 |
Plaque psoriasis |
Anacor Pharmaceuticals, Inc. |
| Asord (becocalcidiol, QRX-101) |
Mild to moderate psoriasis |
CollaGenex Pharmaceuticals, QuatRx, Pfizer |
| Bicillin L-A |
Chronic plaque psoriasis |
University of Tennessee |
| Bimosiamose |
Plaque psoriasis |
Revotar Biopharmaceuticals |
| BMS-582949 |
Plaque psoriasis |
Bristol-Myers Squibb |
| CF101 |
Plaque psoriasis |
Can-Fite Biopharma |
| CP-690,550 |
Plaque psoriasis |
Pfizer |
| CRx-191 |
Plaque psoriasis |
CombinatoRx |
| CRx-197 |
Plaque psoriasis |
CombinatoRx |
| CTA018 |
Plaque psoriasis |
Cytochroma Inc. |
| E6201 |
Plaque psoriasis |
Eisai Inc. |
| Elidel (pimecrolimus, SDZ-ASM-981) |
Plaque psoriasis |
Novartis |
| Fluphenazine |
Plaque psoriasis |
Tufts Medical Center, Immune Control |
| Hectorol Oral (doxercalciferol) |
Plaque psoriasis |
Genzyme |
| Lestaurtinib |
Severe plaque psoriasis |
Cephalon |
| MM-093 |
Plaque psoriasis |
Merrimack Pharmaceuticals |
| Paxceed (micellar paclitaxel) |
Severe plaque psoriasis |
National Cancer Institute |
| R3421/BCX-4208 |
Moderate to severe plaque psoriasis |
Hoffmann-LaRoche, Bio-Cryst Pharmaceuticals Inc. |
| Rambazole (talarozole) |
Moderate to severe plaque psoriasis |
Barrier Therapeutics/ Stiefel, a GSK Company |
| Targretin (Bexarotene) |
Plaque psoriasis |
Ligand Pharmaceuticals, University of Medicine and Dentistry New Jersey |
| tgAAC94 |
Psoriatic arthritis |
Targeted Genetics Corporation |
| VB-201 |
Moderate to severe plaque psoriasis |
VBL Therapeutics |
| Xantryl (Rose Bengal) |
Mild to moderate plaque psoriasis |
Provectus Pharmaceuticals |
I
Phase I
Phase One clinical trials are early stage trials that examine different
dosage levels in a small number of healthy human volunteers, focused on
safety. These drugs are many years from market, and many will not make
it to market, although roughly 70% of these drugs will proceed to Phase
Two trials. Prior to Phase One testing, drugs are tested in cells in
test tubes and in animals.
O
Other Potential Treatments
This is where we post other noteworthy items, not currently in Phase One, Two or Three trials but still worth keeping an eye on.
| DRUG NAME |
DRUG USE (P OR PsA) |
DEVELOPING COMPANY |