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Hope: Psoriasis and Psoriatic Arthritis Treatments in Clinical Trials

While treatments for psoriasis and psoriatic arthritis are expanding, many people continue to need additional options.

What follows is information on the dozens of experimental treatments in development by the pharmaceutical and biotech industries, specifically for psoriasis and psoriatic arthritis.

Many of these will never make it to market, but many of them WILL. Perhaps one of these will help you or one of your loved ones someday.

(Note: We have not included the dozens of treatments being studied for rheumatoid arthritis, even though some of them will almost certainly end up helping psoriasis and/or psoriatic arthritis patients as well.)

If you think you may want to participate in a clinical trial, choose a treatment below or go right to the U.S. Government's clinical trials website for psoriasis and psoriatic arthritis.

[You can also learn more about clinical trials of psoriasis treatments that are already FDA-approved.]

Be hopeful!
III

Phase III

Phase Three clinical trials are advanced trials for drugs that could come to market in anywhere from a few months to a couple years, if the results for safety and effectiveness pan out. These are the drugs closest to market. An estimated 70% to 90% of drugs will succeed in Phase Three trials and reach patients.
DRUG NAME DRUG USE (P OR PsA) DEVELOPING COMPANY
Alga Dunaliella Bardawil Plaque psoriasis Sheba Medical Center
Apremilast Moderate to severe psoriasis, psoriatic arthritis Celgene
Briakinumab - ABT-874 - Ozespa Moderate to severe psoriasis Abbott Labs
Cimzia (certolizumab pegol, CDP870) Plaque psoriasis, psoriatic arthritis UCB, Inc.
Indigo naturalis ointment Plaque psoriasis Chang Gung Memorial Hospital, China
LEO 80190 Plaque psoriasis on face and skin folds LEO Pharma
Protopic (tacrolimus) cream Plaque psoriasis Astellas Pharma Inc
Tasocitinib (CP-690,550) Plaque psoriasis Pfizer
Voclosporin Moderate to severe psoriasis Isotechnika / Lux Biosciences
II

Phase II

Phase Two clinical trials have passed an initial screening in human subjects, and based on that limited data, appear safe. Scientists also typically have some theory at this stage for why a particular compound may help a particular disease. Phase Two studies test a drug for effectiveness. These drugs are typically 3-5 years away from market, provided the Phase Two and later Phase Three trials prove successful. About one-third of drugs that enter Phase One studies proceed successfully through both Phase One and Phase Two trials.
DRUG NAME DRUG USE (P OR PsA) DEVELOPING COMPANY
Actos (Pioglitazone) Plaque psoriasis; insulin resistance Postgraduate Institute of Medical Education and Research, India; Cairo University
AMG 714 Moderate to severe psoriasis Amgen, Genmab
AMG 827 Moderate to severe psoriasis Amgen
AN2728 Plaque psoriasis Anacor Pharmaceuticals, Inc.
Asord (becocalcidiol, QRX-101) Mild to moderate psoriasis CollaGenex Pharmaceuticals, QuatRx, Pfizer
Bicillin L-A Chronic plaque psoriasis University of Tennessee
Bimosiamose Plaque psoriasis Revotar Biopharmaceuticals
BMS-582949 Plaque psoriasis Bristol-Myers Squibb
CF101 Plaque psoriasis Can-Fite Biopharma
CRx-191 Plaque psoriasis CombinatoRx
CRx-197 Plaque psoriasis CombinatoRx
CT327 Psoriasis Creabilis SA
CTA018 Plaque psoriasis Cytochroma Inc.
E6201 Plaque psoriasis Eisai Inc.
Elidel (pimecrolimus, SDZ-ASM-981) Plaque psoriasis Novartis
Fluphenazine Plaque psoriasis Tufts Medical Center, Immune Control
FP187 Moderate to severe plaque psoriasis Forward Pharma
Hectorol Oral (doxercalciferol) Plaque psoriasis Genzyme
Lestaurtinib Severe plaque psoriasis Cephalon
MM-093 Plaque psoriasis Merrimack Pharmaceuticals
Paxceed (micellar paclitaxel) Severe plaque psoriasis National Cancer Institute
R3421/BCX-4208 Moderate to severe plaque psoriasis Hoffmann-LaRoche, Bio-Cryst Pharmaceuticals Inc.
Rambazole (talarozole) Moderate to severe plaque psoriasis Barrier Therapeutics/ Stiefel, a GSK Company
Secukinumab (AIN457) Psoriasis and psoriatic arthritis Novartis Pharmaceuticals
Targretin (Bexarotene) Plaque psoriasis Ligand Pharmaceuticals, University of Medicine and Dentistry New Jersey
tgAAC94 Psoriatic arthritis Targeted Genetics Corporation
VB-201 Moderate to severe plaque psoriasis VBL Therapeutics
Xantryl (Rose Bengal) Mild to moderate plaque psoriasis Provectus Pharmaceuticals
I

Phase I

Phase One clinical trials are early stage trials that examine different dosage levels in a small number of healthy human volunteers, focused on safety. These drugs are many years from market, and many will not make it to market, although roughly 70% of these drugs will proceed to Phase Two trials. Prior to Phase One testing, drugs are tested in cells in test tubes and in animals.
DRUG NAME DRUG USE (P OR PsA) DEVELOPING COMPANY
BTT-1023 Plaque psoriasis Biotie Therapies Oyj
Fezakinumab (ILV-094) Psoriasis Wyeth
O

Other Potential Treatments

This is where we post other noteworthy items, not currently in Phase One, Two or Three trials but still worth keeping an eye on.
DRUG NAME DRUG USE (P OR PsA) DEVELOPING COMPANY
AN2898 psoriasis Anacor Pharmaceuticals
CT637 Severe psoriasis Creabilis
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